Moleculair diagnostic criteria
Eltern, Betreuer, Gesundheitsdienstleister und Lehrer haben oft Bedenken und Fragen zur Pflege und zum Wohlbefinden von Menschen mit Cornelia de Lange syndrome.
The genetic causes of CdLS are complex and research to fully understand all the genetic causes is still ongoing. The genetic make-up of a child cannot be changed after conception.
The CdLS spectrum has been associated with a change (mutation) in genetic material. Usually, CdLS is caused by a change in one of seven genes. Genes are individual genetic instructions in DNA that make us who we are. The seven genes associated with CdLS are: NIPBL, SMC1A, SMC3, RAD21, BRD4, HDAC8 and ANKRD11. A change in one of these genes affects what is known as the cohesin protein complex.
Empfehlung(en)
Moleculair diagnostic criteria
.
unsere Fragen und Antworten unserer Experten